Anti Stress

Emotional Wellness

Ashwagandha is a herb used in Ayurveda (traditional Indian medicine), although more parts of the plant are used, the most common for supplementation is the root.

It is a supplement cataloged within what would be adaptogens, which are a class of compounds that "desensitize" the body to stress. This type of supplement is really effective when the person using it is under low-grade chronic stress; usually a person suffering from it will have symptoms such as bouts of acute depression, mood swings and irritability.

Lavender essential oil extract - the essential oil of lavender included in this supplement contains a high content of linalool together with a significant amount of linalyl acetate, whose beneficial effects for the relief of stress and states of restlessness are comparable to those of drugs based on the reuptake of lavender. serotonin.

The main mechanism of action is a moderate inhibition of voltage dependent calcium channels (VDCC) so it has been found showing some similarities to the anxiolytic drug pregabalin. However, while pregabalin mainly inhibits P/Q-type channels by binding to a modulatory subunit, lavender oil moderately inhibits mainly T-type and N-type channels and to some extent P/Q-type channels. Unlike pregabalin or other medications, our lavender oil extract is free of hypnotic or sedative side effects. With respect to its specific antidepressant-like properties our lavender oil extract improves several aspects of neuroplasticity which seems to be the common final pathway of all antidepressant drugs. As a potential mechanism of its effects on neuroplasticity an activation of the transcription factor CREB via activation of intracellular signaling kinases like PKA and MAPK has been found. Since the concentrations of our lavender oil extract needed to inhibit VDCC function and to improve neuroplasticity are quite similar, the effects our lavender oil extract on PKA or MAPK could constitute a common intracellular signaling cascade leading to VDCC modulation as well as CREB activation and improved neuroplasticity.