DHEA - this hormone, through its interaction with the 3b-HSD enzyme, is transformed into androstenedione, which through the interaction with the 17b-HSD enzyme is transformed into testosterone, and this through the interaction with the 5-AR is transformed into DHT. It must be taken into account that androstenedione can also be transformed into estrone via aromatase.
In addition, it has various beneficial effects at the metabolic level, such as improving the conversion of T4 to T3 in addition to exerting a certain modulating effect at the GR level, not to mention that it has beneficial effects at the level of fat lipolysis. subcutaneous (women) and visceral fat (men). In general terms, it can be said that it exerts an anti-obesogenic action in humans (22, 23, 24).
The body secretes about 25mg of DHEA daily and ideally we want to consume it orally so that it is exposed to the first step of hepatic metabolism and the conversion of DHEA to DHEA-S can take place, which increases its half-life.
Maca Root also called Lepidum Meyenii or Peruvian Ginseng is a plant that originally grows in Peru and Bolivia. The main active ingredient responsible for improving the sexual function of the Maca root is an Alkaloid called Mecamide.
In several studies, the efficacy of Maca root is proven as a libido stimulation and in general of the improvement of sexual function, 50% of participants who did not respond to other alternative therapies.
Tribulus Terrestris or thistle of earth, is a plant that grows in areas of southern Europe, Africa and some regions of Australia. It had been used as a herbal supplement in typical drinks of traditional Chinese and Indian Ayurvedic medicine to alleviate sexual dysfunction mainly.
Despite not having enough scientific evidence to support the possible increases in testosterone levels that it may cause, it has been proven in many clinical trials that it produces a notable improvement in libido through mechanisms not yet established.
Diindolylmethane (DIM) is a phytonutrient, that is, a plant nutrient with important antioxidant properties. In this case, DIM forms part of the composition of multiple vegetables, among which we can highlight broccoli, cabbage, Brussels sprouts, kale, or cauliflower.
DIM intervenes with overactive estrogen by specifically increasing the metabolism of estrogen to 2-hydroxy metabolites that act as a brake on estrogen activity reducing its activity and promoting a more favorable environment for our cells.
DIM is the most effective cruciferous substance to promote a beneficial metabolism of estrogens in men and women. DIM is formed from its precursor, indole-3-carbinol (I3C), which was first used in 1987 in animals and has been shown to be non-toxic and to prevent breast cancer caused by carcinogens. Its mechanism of action seems to be the reduction of the activity of the estrogen receptor system, the stimulation of a beneficial metabolism of estrogens and a selective apoptosis or «programmed cell death» that eliminates damaged cells4.
DIM acts to balance the natural response to estrogen by adjusting the activity of cytochrome metabolic enzymes and specialized estrogen receptor molecules. It also favors the estrogen metabolization pathway in cells to favor the metabolites that prevent cancer, 2-hydroxy and 2-methoxy estradiol.These metabolites then limit cell growth and division, influencing the cell cycle that determines growth and replication. DIM supports the protective mechanism of apoptosis, promoting the beneficial removal of damaged cells.
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