Vitamin C in the form of ascorbic acid is a nutrient that the body needs to form blood vessels, cartilage, muscle, and collagen in bones. Vitamin C is also vital to the body's healing process, acting as a powerful antioxidant to maintain the reduced state of iron and copper ions. It has an important role in collagen synthesis, wound healing, immune function, and neurotransmitter synthesis, hence being a key component for an antioxidant supplement.
NAC (N-acetylcysteine) is an excellent liver protector that has shown efficacy in mitigating hepatotoxicity.
NAC has also shown quite good efficacy in mitigating and preventing cholestasis as studies show.
One particular study administered 300 mg/kg NAC orally for 28 days, and not only did its administration reduce elevations in liver enzyme values that would otherwise be high without administration of the compound, but it also improved kidney function
Another study also investigated NAC's ability to help relieve cholestasis, and also focused a bit more on looking at related kidney effects, and found that in addition to improving liver enzyme values, it had the ability to It greatly improved markers of kidney function and was even able to double the rate of sodium excretion.
This would also indicate that NAC could be very useful for the elimination of sodium and its related water retention in the body, something that could be of particular interest in certain profiles.
However, the problem with NAC is that it has been shown to have a very low oral bioavailability, and this is the reason why high oral doses are used in studies for the treatment of Paracetamol poisoning compared to when it is administered via route. IV (Intravenous).
Aside from NAC's ability as a nephroprotective (kidney-protective) and hepatoprotective (liver-protective) agent, it is well documented that it possesses a myriad of other benefits to the body; This includes, among others, the treatment of lung diseases, lung problems related to smoking and COPD, the treatment of psychiatric disorders such as schizophrenia, bipolar disorder, depression, improvement of the lipid profile, OCDs.
SAME is the form in which the amino acid methionine is present linked to an ATP molecule and acts in the body as a "donor" co-substrate of methyl groups, which are responsible for acting on the body's metabolic reactions as regulators.
S-adenosyl methionine (SAMe) is an endogenous cellular metabolite, donor of methyl groups in most biological transmethylation reactions, which actively participates in the metabolism of sulfur amino acids (cystine, cysteine or taurine) and glutathione, and It is distributed throughout all body tissues and fluids.
SAMe also has an important protective effect on the liver in situations of intoxication (D-galactosamine, CCl4, alcohol or acetaminophen) and, on the other hand, it antagonizes the increase in bile secretion induced by estrogens. SAMe prevents the depletion of intracellular glutathione in response to free radicals and is more effective than glutathione in scavenging hydroxyl radicals.
ALA is an amphipathic acid, so it has the ability to dissolve both in an aqueous medium and in a fatty medium, which is why it is called "universal antioxidant" and can act both intracellularly and extracellularly, anywhere any level within the body.
ALA not only acts as a powerful scavenger of free radicals and metal chelators, but can also recycle other antioxidants such as glutathione, Coenzyme Q10, and vitamins C and E.
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