If you have spent any time researching SARMs, you have probably come across S23 and seen it compared to Trenbolone, the strongest anabolic steroid on the planet according to your fav gymbro. And while no SARM truly matches the raw power of Tren, S23 is as close as it gets in the world of SARMs.
S23 is not your average “mild” SARM like Ostarine or LGD-4033—it is a hardcore, high-androgenic compound that delivers insane strength, muscle hardness, and extreme fat loss, but also comes with heavy testosterone suppression and Tren-like side effects.
So, is S23 really the Tren of SARMs? Let’s break it down!
What is S23 and Why is it So Strong?
S23 is a Selective Androgen Receptor Modulator (SARM) that was originally researched as a male contraceptive (which already tells you something about its impact on testosterone levels).
It is considered the most potent SARM for muscle growth, strength, and fat loss, but it is also the most suppressive, meaning your natural testosterone is going to tank while using it.
Why S23 is the Strongest SARM:
Higher androgenic activity than other SARMs – Acts more like an anabolic steroid than a traditional SARM.
Extreme muscle hardness and vascularity – Gives that “dry, grainy” look similar to Tren.
Brutal strength gains – Users report dramatic increases in strength within 1-2 weeks.
Intense fat loss – Works almost like a hybrid of Winstrol and Tren, stripping body fat rapidly.
Strong testosterone suppression – Almost guaranteed to shut down natural production completely.
S23 is not for beginners, but for those looking for the hardest-hitting, most aggressive SARM available, this is it.
How Does S23 Compare to Tren?
S23 is often called the “Tren of SARMs” because its effects mimic Tren in many ways, both in terms of muscle growth and side effects.
The Benefits of S23: Why People Use It Despite the Suppression
Even with severe testosterone shutdown, people still use S23 because it delivers results that most SARMs simply cannot match.
Insane Strength Gains
S23 is one of the strongest SARMs in terms of raw power output. Users report:
Faster progression on big lifts.
Heavier weights feeling easier in just a couple of weeks.
Increased explosiveness and aggression in the gym.
If you want to lift heavier and push through plateaus, S23 delivers.
Next-Level Muscle Hardness and Definition
S23 gives that dry, vascular, shredded look that most people chase when cutting.
Zero water retention – Unlike some SARMs that cause mild bloating, S23 keeps muscles tight and defined.
Increased muscle density – Users report a harder, “more compact” look, similar to Winstrol or Masteron.
Veins popping even at higher body fat levels.
This makes S23 a great choice for cutting or recomposition cycles.
Fat Loss Acceleration
S23 has a fat-burning effect similar to Tren, meaning it helps strip fat while maintaining muscle and strength.
Works by increasing basal metabolic rate (BMR), making it easier to stay lean.
Helps maintain strength even in a deep calorie deficit.
Gives that “shrink-wrapped” look when combined with a low-carb diet.
If getting shredded while staying strong is the goal, S23 is one of the best SARMs for the job.
The Downsides: Why S23 is NOT for Everyone
S23 is not a mild compound, and the side effects prove it.
Complete Testosterone Shutdown
S23 is by far the most suppressive SARM, meaning:
Expect full shutdown of natural testosterone production.
HCG won’t prevent suppression—it needs a full PCT.
Running S23 without test base = feeling like garbage.
If you are not prepared for a proper PCT, do not run S23.
Night Sweats and Insomnia
Just like Tren, S23 causes:
Excessive sweating at night (waking up drenched).
Difficulty falling and staying asleep.
Overheating, especially in warm climates.
This is a major dealbreaker for some people, so be aware before using it.
Aggression and Mood Swings
S23 has noticeable androgenic effects, meaning:
Higher irritability and short temper.
More intense focus/aggression in the gym.
Euphoric at times, but also potential mood crashes.
This is not as extreme as Tren, but it is something to watch out for.
How to Use S23 for Maximum Gains and Minimal Side Effects
Dosage Recommendations:
Beginners: Do not start with S23.
Intermediate Users: 10-20 mg/day.
Advanced Users: 20-30 mg/day.
Cycle Length:
6-8 weeks max (due to heavy suppression).
Should You Use a Test Base?
Yes. If you do not want to feel like complete garbage mid-cycle, running a testosterone base (TRT or low-dose Test E/C) is recommended.
If running S23 solo, expect total suppression and all the symptoms that come with it.
PCT Requirements
S23 requires a full PCT—do not expect a natural recovery without it.
Clomid 50/50/25/25 or Enclomiphene.
Natural test boosters will NOT be enough.
Final Thoughts
S23 is not a beginner SARM, it is the closest thing to Tren in the SARM world, meaning it:
Delivers insane strength, muscle hardness, and fat loss.
Comes with full shutdown, night sweats, and mood swings.
Requires serious post-cycle therapy to recover.
If you are an experienced user looking for a hardcore compound, S23 is one of the strongest SARMs available.
But if you are new to SARMs, not ready for full suppression, or don’t want Tren-like side effects, you are better off sticking with something milder.
