Lions mane also known as Hericium erinaceus, Lion’s Mane is an edible mushroom used extensively in traditional Chinese and Japanese medicine, it contains some some pretty unique compounds such as erinacines, erinacea lactones, glycoproteins, hericerins, and polysaccharides (beta-glucans).
One of the main benefits that it has is that it has been shown to increase the amount of the protein Nerve Growth Factor in the brain, which improves cognition by promoting neuronal growth, reducing inflammation, and supporting overall brain health.
Lions Mane has been shown to enhance acetylcholine and choline acetyltransferase (the enzyme that produces acetylcholine) levels in the blood and hypothalamus, improving nerve cell communication and having neuroprotective properties. Also it decreases amyloid beta plaque buildup in the brain, which has neurotoxic properties.
L-Tyrosine is a nonessential amino acid, It’s used to create several powerful catecholamine neurotransmitters including epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine. This neurotransmitters enhance have neuroprotective properties and have a powerful nootropic effect, increasing focus and alertness.
Rhodiola Rosea This natural herb has been used anecdotally for centuries in traditional Chinese medicine and belongs to the adaptogens class.
There are 20 species of Rhodiola used in traditional medicine, but Rhodiola rosea is the most studied one.
Rhodiola Rosea main bioactive compound are Rosavins, although it has also a high content of salidrosides, in a 3:1 ratio, most of the benefits como from the salidrosides content, but it has been shown that the combination of Rosavins and salidrosides enhances the Salidrosides adaptogen effects.
It regulates the HIF-1 activity, It’s a gene that helps activate numerous transcription factors that regulate oxygen delivery and metabolic functioning, hence helping with the brain oxygenation.
Neurotransmitters are a key factor for improving brain function, once a neurotransmitter activates a signal, one of two things happens: it’s either taken back up by the neuron that released it, or it’s degraded. Multiple enzymes catalyze the degradation reactions, but the two most prevalent are monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT).
Rosarins and Salidrosides have been shown to improve MAO inhibition.
Also it has been shown that Rhodiola Rosea significantly stimulates NPY, NPY also called Neuropeptide Y, is a peptide mainly found in the cortex that among all its properties has been associated with resistance to stress and anxiety.
Noopept also known as N-phenylacetyl-L-polyglycine ethyl ester, Noopept is a nootropic peptide that was created to be very similar to Piracetam by Russian scientists.
It works mainly by modulating the acetylcholine system, as well as modulating AMPA receptors, acting similarly to Piracetam but more effectively.
Also it works via an antioxidant effect, the anti-inflammatory action, and the ability to inhibit the neurotoxicity of excess calcium and glutamate, and to improve the blood rheology.
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