Ephedra extract or Ma Huang is a plant that has been used in Chinese medicine, the ephedrine alkaloids found in the ephedra plant and therefore in its extract have an amazing ability to aid in weight loss and fat burning.
Ephedrine alkaloids acts both as an α and β adrenergic agonist, stimulating the release of norepinephrine. Increased circulating norepinephrine in the body then acts on brown adipose tissue and skeletal muscle by increasing cyclic adenosine monophosphate (cAMP) levels. This causes a thermogenic effect, raising bodily heat production and increasing energy consumption.
Unfortunately the body's negative feedback systems quickly activate to normalize metabolism. This takes the form of elevated phosphodiesterase enzyme activity within the cells, as well as prostaglandin release in the synaptic junctions; both of these degrade cAMP and mitigate the thermogenic effects, which is why we use ephedra extract together with caffeine and aspirin, to avoid this effect.
Caffeine is what often makes a pre-workout a pre-workout, it is a very useful ingredient that, as we will see later, apart from having direct effects on fat and weight loss, has a synergistic effect with the rest of the stack.
It has a direct effect on lipid metabolism since its consumption increases oxygen consumption and the use of free fatty acids (FFA) as an energy source, thus promoting the use of lipids by the cell.
In addition, caffeine helps at the level of mental fatigue as a nootropic, this is because caffeine can block adenosine receptors in the brain, with various effects:
Prevents drowsiness and increases resistance to fatigue.
It increases the levels of dopamine and adrenaline, and thus increases concentration, mental and physical power.
Dopamine and adrenaline are two neurotransmitters responsible for the feeling of euphoria.
Caffeine inhibits the production of phosphodiesterase inside the cell and therefore slows the degradation of cAMP. It also binds with and competitively inhibits adenosine receptors in the brain, triggering the release of epinephrine and increasing cAMP levels.
Aspirin is a type of medicine called a "salicylate." Aspirin is used to reduce pain, inflammation (swelling), and fever due to its nonselective cyclooxygenase inhibitory effect.
Aspirin inhibits prostaglandin production outside of the cells, which, in conjunction with caffeine, greatly prolongs the thermogenic effects and increased metabolism by sustaining elevated cAMP levels.
N-Phenylethyl Dimethylamine Citrate - This is our special addition to the ECA stack, the N-Phenylethyl Dimethylamine Citrate is an alkaloid extracted from the Eria Jarensis plant, being scientifically considered to be a is a substituted phenethylamine, basically it is a modified Phenethylamine, therefore having the effects of increasing drastic in dopamine levels and therefore providing a feeling of euphoria and well-being, but with several advantages.
The first of these is the duration of its effects, thanks to the N,N' dialkyl group, the molecule is partially protected against MAO enzymes, which are responsible for reducing the amino group and therefore preventing them from remaining attached. to dopamine receptors, this provides a very long half life compared to that of a simple Phenethylamine which lasts only 5 minutes.
The other advantage is that, thanks to its alkyl groups, N-Phenylethyl Dimethylamine Citrate has improved lipophilicity, being able to cross the blood-brain barrier much more effectively.
Yohimbine It acts mainly as an antagonist of Alpha-2 adrenergic receptors, making it very useful for eliminating stubborn fat as well as increasing adrenaline levels in the body.
By inhibiting autoreceptors on presynaptic noradrenergic neurons, yohimbine may increase norepinephrine release as the negative feedback inhibition cycle is interrupted.
Yohimbine acts on the adrenergic receptor system of fat cells, which regulates thermogenesis.
The beta subunits of adrenergic receptors (targets of ephedrine) can be considered stimulants for fat loss, since they increase the activity of the enzyme adenyl cyclase and subsequently the levels of cAMP.
Alpha subunits are more suppressive of fat metabolism, in which their activation reduces adenyl cyclase activity and lowers cAMP (specifically alpha-2) levels.
Yohimbine is a selective alpha-2 adrenergic receptor antagonist (inactivator), which inhibits the activation of the suppressor set of receptors and preserves the activity of adenyl cyclase and the effects mediated through beta receptors, also yohimbine can induce the fat loss indirectly through the release of adrenaline; adrenaline itself is an activator of beta-adrenergic receptors, however this increase in adrenaline may disappear over time reaching negligible levels 2 weeks after daily intake,
Increases in plasma free fatty acids and alpha2-adrenergic receptor density remain similar at both time points, suggesting that yohimbine selectively misses the spike in epinephrine but not the direct fat-burning effects of the receptor.
1,3-dimethylamylamine also known as DMAA is the final addition to our ECA Extreme, the most powerful version of our ECA, 1,3-dimethylamylamine (DMAA) is an aliphatic amine that possesses a structure similar to that of amphetamines, for the same reason it is considered one of the most powerful stimulants currently on the market.
DMAA increases both the levels of norepinephrine and the levels of dopamine in the human body, norepinephrine acts both as a hormone and as a neurotransmitter, being considered on paper as a catecholamine, this mainly has three advantages, the first of which is the of a state of alertness and constant energy, with characteristics similar to those of combining a nootropic with a stimulant, the second one is to increase the heart rate and blood flow, the last advantage is that glucose is forced to be released from glycogen storages, improving performance during training.
Thanks to increasing dopamine levels in the body, DMAA is able to improve mood and give a feeling of euphoria and focus while its effect lasts.
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