Ephedra extract or Ma Huang is a plant that has been used in Chinese medicine, the ephedrine alkaloids found in the ephedra plant and therefore in its extract have an amazing ability to aid in weight loss and fat burning.
Ephedrine alkaloids act both as an α and β adrenergic agonist, stimulating the release of norepinephrine. Increased circulating norepinephrine in the body then acts on brown adipose tissue and skeletal muscle by increasing cyclic adenosine monophosphate (cAMP) levels. This causes a thermogenic effect, raising bodily heat production and increasing energy consumption.
Unfortunately the body's negative feedback systems quickly activate to normalize metabolism. This takes the form of elevated phosphodiesterase enzyme activity within the cells, as well as prostaglandin release in the synaptic junctions; both of these degrade cAMP and mitigate the thermogenic effects, which is why we use ephedra extract together with caffeine and aspirin, to avoid this effect.
Caffeine is what often makes a pre-workout a pre-workout, it is a very useful ingredient that, as we will see later, apart from having direct effects on fat and weight loss, has a synergistic effect with the rest of the stack.
It has a direct effect on lipid metabolism since its consumption increases oxygen consumption and the use of free fatty acids (FFA) as an energy source, thus promoting the use of lipids by the cell.
In addition, caffeine helps at the level of mental fatigue as a nootropic, this is because caffeine can block adenosine receptors in the brain, with various effects:
Prevents drowsiness and increases resistance to fatigue.
It increases the levels of dopamine and adrenaline, and thus increases concentration, mental and physical power.
Dopamine and adrenaline are two neurotransmitters responsible for the feeling of euphoria.
Caffeine inhibits the production of phosphodiesterase inside the cell and therefore slows the degradation of cAMP. It also binds with and competitively inhibits adenosine receptors in the brain, triggering the release of epinephrine and increasing cAMP levels.
Aspirin is a type of medicine called a "salicylate." Aspirin is used to reduce pain, inflammation (swelling), and fever due to its nonselective cyclooxygenase inhibitory effect.
Aspirin inhibits prostaglandin production outside of the cells, which, in conjunction with caffeine, greatly prolongs the thermogenic effects and increased metabolism by sustaining elevated cAMP levels.
N-Phenylethyl Dimethylamine Citrate - this is our special addition to the ECA stack, the N-Phenylethyl Dimethylamine Citrate is an alkaloid extracted from the Eria Jarensis plant, being scientifically considered to be a is a substituted phenethylamine, basically it is a modified Phenethylamine, therefore having the effects of increasing drastic in dopamine levels and therefore providing a feeling of euphoria and well-being, but with several advantages.
The first of these is the duration of its effects, thanks to the N,N' dialkyl group, the molecule is partially protected against MAO enzymes, which are responsible for reducing the amino group and therefore preventing them from remaining attached. to dopamine receptors, this provides a very long half life compared to that of a simple Phenethylamine which lasts only 5 minutes.
The other advantage is that, thanks to its alkyl groups, N-Phenylethyl Dimethylamine Citrate has improved lipophilicity, being able to cross the blood-brain barrier much more effectively.
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